Diffusion Models and Metrics

Before practicum on Friday, please complete following:

During practicum on Friday:

Diffusion MRI models

Model/Method B-table requirements Handle Free Water Quantify Restricted Diffusion Resolve Multiple Fibers Metrics
DTI B0, >= 1 b-value(s) No (except for DTI-FWE) No No (except for Multi-Tensor) fa, ad, rd, md
DKI B0, >= 2 b-values Yes Yes No (except for Multi-Tensor) ak, rk, mk
NODDI B0, >= 2 b-values Yes Yes No (except for Multi-Fiber NODDI ) iso, odi, ndi (icvf)
GQI B0, >= 1 b-value(s) Yes Yes Yes qa, iso, rdi
CSD 1 b-value No No Yes afd
CSD-MSMT >= 2 b-values Yes Yes Yes afd

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Hands-on: DTI, GQI, and QSDR Reconstruction

Hands-on: dMRI analysis


Practicum assignment: ROI-based and Track-based analysis comparing SCA2 with controls

  1. Download the SCA2 Diffusion Tensor Imaging study
  2. Reconstruct data at [Step T2 Reconstruction] using QSDR
  3. Create connectometry databases using [Step C2: Create a connectometry Database], one for nqa, and one for fa.
  4. Open the database at [Step T3: Fiber Tracking]
  5. Use region-based analysis to get metrics (nqa, fa) from patients and controls and compare.
  6. Use tract-based analysis to get metrics (nqa, fa) from patients and controls and compare.
  7. Segment CST into segmentation to get metrics (nqa, fa) and compare them between patients and controls.